Aachen University of Applied Sciences, Germany

25 years with capacitive field-effect biosensors – a short review and current trends

CV: Michael J. Schöning received his diploma degree in electrical engineering (1989) and his PhD in the field of semiconductor-based microsensors for the detection of ions in liquids (1993), both from the Karlsruhe University of Technology. In 1989, he joined the Institute of Radiochemistry at the Research Centre Karlsruhe. Since 1993, he has been with the Institute of Thin Films and Interfaces (now, Institute for Biological Information Processing, IBI-3) at the Research Centre Jülich, and since 1999 he was appointed as full professor at Aachen University of Applied Sciences, Campus Jülich. Since 2006, he serves as a director of the Institute of Nano- and Biotechnologies (INB) at the Aachen University of Applied Sciences. His main research subjects concern silicon-based chemical and biological sensors, thin-film technologies, solid-state physics, microsystem and nano(bio-)technology.

Abstract: Among the multitude of concepts and different types of chemical sensors and biosensors discussed in the literature, the strategy to integrate chemical or biological recognition elements together with semiconductor-type field-effect devices is one of the most attractive approaches. In this context, typical examples are represented by the capacitive EIS (electrolyte-insulator-semiconductor) sensor, the LAPS (light-addressable potentiometric sensor) or the ISFET (ion-sensitive field-effect transistor). This presentation gives a 25 years review as well as considers current trends in the area of capacitive field-effect chemical and biological sensing. The sensors have been dealing with different receptor molecules (such as enzymes, polyelectrolytes or DNA molecules), various immobilization strategies and fabrication techniques as well as the detection of charged macromolecules by their intrinsic molecular charge.